Kloer H, Hoogen H, Nieschlag E
Int J Androl. 1980 Apr;3(2):121-9. doi: 10.1111/j.1365-2605.1980.tb00101.x.
The effectiveness of high-dose testosterone undecanoate administered orally in suppressing spermatogenesis and eliciting the rebound-phenomenon was investigated in an uncontrolled clinical trial. Five men with fertility disturbances were treated for 10--12 weeks with 3 x 80 mg testosterone undecanoate daily. One patient achieved azoospermia and 2 oligospermia below 10 mill/ml, 1 suppressed to 27 mill/ml and 1 patient showed no effect. After cessation of treatment, 3 patients showed an increase in sperm concentration to greater than 50% of control values, one showed an increase of 35% and one showed a decrease in sperm count. The preliminary data suggest that although complete suppression of spermatogenesis is not uniformly achieved, a controlled study on the effects of high doses of testosterone undecanoate in male infertility may now by warranted.
