Rivier C, Rivier J, Vale W
Science. 1980 Oct 3;210(4465):93-5. doi: 10.1126/science.6774418.
Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-N alpha-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.
给成年雄性大鼠连续2周注射一种强效促性腺激素释放激素（GnRH）拮抗剂[Ac-脱氢-Pro1，对氯-D-苯丙氨酸2，D-色氨酸3,6]-Nα-甲基亮氨酸7-GnRH，导致睾酮分泌减少、性器官重量减轻以及精子发生受到破坏。这些结果证明了促性腺激素释放激素在维持生殖功能中的重要作用，并对男性生育能力的调节具有启示意义。
