用P 40对二甲基苯并蒽诱导的大鼠乳腺癌进行免疫治疗后的组织病理学改变。
Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma.
作者信息
Hollmann K H, Verley J M
出版信息
Experientia. 1980 Oct 15;36(10):1213-5. doi: 10.1007/BF01976136.
PMID:6774883
Abstract
Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.
摘要
对原发性诱发乳腺癌的雌性斯普拉格-道利大鼠使用一种新型免疫刺激剂（P 40）进行治疗。描述了在肿瘤、淋巴结、肝脏和脾脏中遇到的组织病理学改变。与全身治疗相比，瘤内注射引起网状内皮系统更广泛的反应，尤其是引流淋巴结中更强烈的反应。
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