Barjaktarovic N, Savage J R
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Jun;37(6):667-75.
The irradiation of human lymphocytes with five doses of 250 kV X-rays and five doses of d(42MeV)-Be neutrons was performed in order to obtain dose-response curves for both radiation qualities. By using the FPC technique, aberration scoring was confined to first division cells only and dose-response curves were obtained at three sampling times. Sampling time independence was observed for chromosome-type aberrations and common curves could be fitted, confirming homogeneity of the initial lymphocyte population. R.b.e. values between 1x1 and 8x8 were obtained for dicentric yields between 0x01 and 2x0 per cell. Some variabilities were encountered for other aberration types. Mitotic delay showed an r.b.e. of 1x75. There was no evidence for any induction of SCE by either X-rays or neutrons, up to the highest doses used.
为了获得两种辐射品质的剂量响应曲线，对人类淋巴细胞进行了五次剂量的250 kV X射线和五次剂量的d(42MeV)-Be中子照射。通过使用FPC技术，畸变评分仅限于首次分裂细胞，并且在三个采样时间获得了剂量响应曲线。对于染色体型畸变，观察到采样时间的独立性，并且可以拟合共同曲线，证实了初始淋巴细胞群体的同质性。对于每个细胞中双着丝粒产率在0.01至2.0之间的情况，相对生物效应（RBE）值在1.1至8.8之间。对于其他畸变类型，存在一些变异性。有丝分裂延迟的RBE为1.75。在所用的最高剂量之前，没有证据表明X射线或中子会诱导姐妹染色单体交换（SCE）。
