Mitsumoto H, Wilbourn A J, Goren H
Muscle Nerve. 1980 Sep-Oct;3(5):403-12. doi: 10.1002/mus.880030504.
Clinical, electrodiagnostic, and morphological studies were performed on three patients with localized hypertrophic neuropathy (LHN). LHN is characterized clinically by slowly progressive motor mononeuropathy without significant pain or numbness. Nerve conduction studies and needle electrode examination show severe focal motor and sensory axonal loss. Morphological findings in the localized areas of enlarged nerves are different from those of generalized hypertrophic neuropathy, entrapment neuropathy, and neurofibroma, and consist of primary perineurial cell hyperplasia. The tumor is thus a perineurioma. This rare tumor can occur both in generalized neurofibromatosis and in isolated form and appears to be the cause of localized hypertrophic neuropathy.
对三名局限性肥厚性神经病（LHN）患者进行了临床、电诊断和形态学研究。LHN的临床特征为缓慢进展的运动单神经病，无明显疼痛或麻木。神经传导研究和针电极检查显示严重的局灶性运动和感觉轴突丧失。神经增粗局部区域的形态学表现不同于全身性肥厚性神经病、卡压性神经病和神经纤维瘤，主要由神经束膜细胞增生组成。因此，该肿瘤为神经束膜瘤。这种罕见肿瘤可发生于全身性神经纤维瘤病，也可呈孤立形式出现，似乎是局限性肥厚性神经病的病因。
