Carlen P L, Kapur B, Huszar L A, Lee M A, Moddel G, Singh R, Wilkinson D A
Neurology. 1980 Sep;30(9):956-62. doi: 10.1212/wnl.30.9.956.
Significant cerebrospinal fluid (CSF) acidosis was evident in 80 chronic alcoholics (mean pH, 7.25 +/- 0.06) who were compared with 14 neurologic controls (mean pH, 7.31 +/- 0.02). Acidosis persisted for many weeks after the last drink, and there was no associated systemic acidosis. CSF pH correlated significantly with CSF anion gap, suggesting a primary cerebral metabolic abnormality. Even though one-quarter of the alcoholic patients had a CSF pH less than 7.21, mental impairment was less than expected for the degree of CSF acidosis noted.
80名慢性酒精中毒者的脑脊液（CSF）出现明显酸中毒（平均pH值为7.25±0.06），并与14名神经系统对照者（平均pH值为7.31±0.02）进行了比较。酸中毒在最后一次饮酒后持续数周，且无相关的全身性酸中毒。脑脊液pH值与脑脊液阴离子间隙显著相关，提示原发性脑代谢异常。尽管四分之一的酒精中毒患者脑脊液pH值低于7.21，但精神障碍程度低于所观察到的脑脊液酸中毒程度所预期的情况。
