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向中脑导水管周围-脑室周围灰质注射吗啡可减轻隔区的高反应性。

Morphine injections into the periaqueductal-periventricular gray attenuate septal hyperreactivity.

作者信息

Gage F H, Valdes J J, Thompson R G

出版信息

Psychopharmacology (Berl). 1980;70(1):113-4. doi: 10.1007/BF00432380.

DOI:10.1007/BF00432380
PMID:6775329
Abstract

Animals with septal lesion-induced reactivity were injected with 2 dose levels of morphine in the periaqueductal-periventricular gray. Both doses of morphine transiently attenuated the reactivity. Naloxone injected IP significantly antagonized the morphine attenuation of the septal-lesion induced reactivity.

摘要

对患有中隔损伤诱导反应性的动物，在导水管周围-脑室周围灰质区域注射2个剂量水平的吗啡。两种剂量的吗啡均能短暂减弱反应性。腹腔注射纳洛酮能显著拮抗吗啡对中隔损伤诱导反应性的减弱作用。

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本文引用的文献

1
Pain mechanisms and the frontal lobes; a study of prefrontal lobotomy for intractable pain.疼痛机制与额叶；一项关于额叶前部脑叶切除术治疗顽固性疼痛的研究。
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Subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat.情绪行为中的皮层下机制：白化大鼠隔前脑损伤后的情感变化。
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Further analysis of sensory inattention following lateral hypothalamic damage in rats.
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Paradoxical effects after microinjection of morphine in the periaqueductal gray matter in the rat.大鼠中脑导水管周围灰质微量注射吗啡后的矛盾效应。
Science. 1974 Sep 20;185(4156):1055-7. doi: 10.1126/science.185.4156.1055.
5
Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat.通过向大鼠中脑导水管周围灰质内微量注射吗啡所产生的镇痛和反应过度
Behav Biol. 1974 Jul;11(3):303-13. doi: 10.1016/s0091-6773(74)90548-3.
6
L-Dopa reduces hyperreactivity induced by septal lesions in rats.左旋多巴可降低大鼠中隔损伤诱发的反应过度。
Behav Biol. 1976 Jun;17(2):213-8. doi: 10.1016/s0091-6773(76)90478-8.
7
Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray.对大鼠中对直接应用吗啡敏感的脑区进行系统检查：中脑导水管周围灰质内差异效应的观察
Brain Res. 1976 Sep 10;114(1):83-103. doi: 10.1016/0006-8993(76)91009-x.