Risch C, Kripke D, Janowsky D
Psychopharmacology (Berl). 1980;70(1):79-82. doi: 10.1007/BF00432374.
The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of methylphenidate (25 mg/kg and 50 mg/kg) increased locomotion and sniffing behavior. Flurazepam 3.0 mg/kg augmented methylphenidate-induced stereotyped gnawing behavior and stereotypy. Flurazepam significantly decreased locomotion and sniffing, but did not interact with methylphenidate's effects on locomotion and sniffing.
在白天和夜间实验中，评估了氟西泮（0.0、0.5和3.0毫克/千克）对哌甲酯诱导的刻板行为、啃咬、嗅探和运动增加的影响，实验对象为瑞士韦伯斯特小鼠。哌甲酯（50毫克/千克）增加了总体刻板行为和刻板啃咬行为；两剂哌甲酯（25毫克/千克和50毫克/千克）增加了运动和嗅探行为。3.0毫克/千克的氟西泮增强了哌甲酯诱导的刻板啃咬行为和刻板行为。氟西泮显著降低了运动和嗅探行为，但与哌甲酯对运动和嗅探行为的影响没有相互作用。
