冠状动脉内注射硝酸甘油对人体心肌侧支循环灌注分布的影响。
Effect of intracoronary glyceryl trinitrate on perfusion distribution in the collateralised human myocardium.
作者信息
Wald R W, Sternberg L, Feiglin D H, Morch J E
出版信息
Br Heart J. 1980 Aug;44(2):175-8. doi: 10.1136/hrt.44.2.175.
Abstract
The effect on myocardial perfusion distribution of intracoronary glyceryl trinitrate in a dose (60 micrograms) insufficient to cause alterations in systemic blood pressure or heart rate was studied in eight patients with angiographically demonstrated collaterals from the left coronary system to the distal right coronary artery. Double isotope imaging using technetium-99m and iodine-131 labelled albumin macroaggregates allowed each patient to serve as his own control. The reproducibility of the imaging and data handling techniques was shown in 12 control patients. Glyceryl trinitrate caused a significant diminution in the collateral-mediated fractional perfusion while increasing that of the native coronary bed.
摘要
在8例经血管造影证实有从左冠状动脉系统至右冠状动脉远端侧支循环的患者中，研究了冠状动脉内注入剂量为60微克的硝酸甘油对心肌灌注分布的影响，该剂量不足以引起全身血压或心率改变。采用锝-99m和碘-131标记的白蛋白大聚合体进行双同位素成像，使每位患者可作为自身对照。在12例对照患者中显示了成像和数据处理技术的可重复性。硝酸甘油使侧支循环介导的灌注分数显著降低，同时增加了自身冠状动脉床的灌注分数。
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