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Changes in morphology and hormone dependency following transplantation of rat 9,10-Dimethyl-1,2-benzanthracene-induced mammary adenocarcinoma.大鼠9,10-二甲基-1,2-苯并蒽诱导的乳腺腺癌移植后形态学和激素依赖性的变化
Eur J Cancer (1965). 1976 Mar;12(3):189-94. doi: 10.1016/0014-2964(76)90240-1.
8
Oestrogen receptors in transplantable ovary-independent, mammary tumours of the rat.大鼠可移植性非卵巢依赖性乳腺肿瘤中的雌激素受体
Eur J Cancer (1965). 1978 Jan;14(1):83-90. doi: 10.1016/0014-2964(78)90141-x.
9
Estrogen and prolactin receptor concentrations in rat mammary tumors and response to endocrine ablation.大鼠乳腺肿瘤中雌激素和催乳素受体浓度及对内分泌切除的反应
Cancer Res. 1976 Feb;36(2 Pt 1):354-8.
10
Hormonal status and steroid metabolism in two transplantable rat mammary tumours.两种可移植性大鼠乳腺肿瘤中的激素状态与类固醇代谢
Br J Cancer. 1979 Feb;39(2):200-4. doi: 10.1038/bjc.1979.32.

连续传代对大鼠乳腺癌内分泌反应和类固醇代谢的影响。

Effects of serial passage on the endocrine response and steroid metabolism of a rat mammary carcinoma.

作者信息

Miller W R

出版信息

Br J Cancer. 1980 Aug;42(2):326-30. doi: 10.1038/bjc.1980.234.

DOI:10.1038/bjc.1980.234
PMID:6775657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010384/
Abstract

A rat mammary carcinoma induced by 7-12 dimethylbenzanthracene was serially transplanted into successive generations of thymectomized host animals. After its 2nd passage, the growth of the tumour appeared hormone-dependent, regressing after oophorectomy and regrowing with administration of oestradiol 17 beta to the host. Third-generation transplanted tumours, however, showed only a transient regression after oophorectomy, and the growth of tumours after further passages appeared ovary-independent. Loss in hormone dependency was not accompanied by histological changes. There was however a progressive increase with successive transplantation in the ability of tumours to metabolize 7 alpha [3H] testosterone in vitro. This was accounted for by raised conversion to 5 alpha androstanediol.

摘要

用7,12-二甲基苯并蒽诱发的大鼠乳腺癌被连续移植到连续几代胸腺切除的宿主动物体内。在第二代移植后，肿瘤的生长表现出激素依赖性，卵巢切除后肿瘤消退，给宿主注射17β-雌二醇后肿瘤重新生长。然而，第三代移植肿瘤在卵巢切除后仅表现出短暂的消退，进一步传代后的肿瘤生长似乎不依赖卵巢。激素依赖性的丧失并未伴有组织学变化。然而，随着连续移植，肿瘤在体外代谢7α [3H]睾酮的能力逐渐增加。这是由于向5α-雄甾二醇的转化率提高所致。