Fosså S D, Klepp O, Aakvaag A
Br J Urol. 1980 Apr;52(2):151-7. doi: 10.1111/j.1464-410x.1980.tb02946.x.
In patients treated for malignant testicular tumours without clinical and/or radiological signs of tumour, the following serum hormone levels were found: In 15% of the patients there was a slight to moderate rise in luteinising hormone (LH) levels (up to 6 micrograms/l) due to increased pituitary gonadotrophin production; this was particularly evident soon after radiotherapy/chemotherapy. In 50% of the patients there was a slight to marked increase in follicle stimulating hormone (FSH) levels (up to 11 micrograms/l), especially after radiotherapy/chemotherapy. Serum testosterone levels were in the low range (up to 20 nmol/l) in the majority of the hemicastrated patients regardless of previous treatment. A slight to moderate rise in serum oestradiol-17 beta and serum prolactin levels was noted. During combination chemotherapy with vincristine, Adriamycin D, cyclophosphamide, actinomycin D and medroxyprogesterone acetate the serum testosterone levels were extremely low (below 6 nmol/l) with LH and FSH levels within the normal range. The decrease in testosterone levels was reversible after completion of the combination chemotherapy.
在接受治疗的无临床和/或放射学肿瘤迹象的恶性睾丸肿瘤患者中，发现了以下血清激素水平：15%的患者由于垂体促性腺激素分泌增加，黄体生成素（LH）水平有轻度至中度升高（高达6微克/升）；这在放疗/化疗后不久尤为明显。50%的患者促卵泡激素（FSH）水平有轻度至显著升高（高达11微克/升），尤其是在放疗/化疗后。大多数半侧睾丸切除患者的血清睾酮水平处于低范围（高达20纳摩尔/升），无论先前的治疗如何。血清雌二醇-17β和血清催乳素水平有轻度至中度升高。在使用长春新碱、阿霉素D、环磷酰胺、放线菌素D和醋酸甲羟孕酮联合化疗期间，血清睾酮水平极低（低于6纳摩尔/升），LH和FSH水平在正常范围内。联合化疗完成后，睾酮水平的降低是可逆的。
