接受苯巴比妥治疗的儿童垂体对促性腺激素释放激素和促甲状腺激素释放激素的反应性。
Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in children receiving phenobarbitone.
作者信息
Masala A, Meloni T, Alagna S, Rovasio P P, Mele G, Franca V
出版信息
Br Med J. 1980 Nov 1;281(6249):1175-7. doi: 10.1136/bmj.281.6249.1175.
The effect of long-term treatment with phenobarbitone on pituitary responsiveness to gonadotrophin-releasing hormone and thyrotrophin-releasing hormone was studied in 20 boys being treated with the drug to prevent febrile convulsions. Baseline concentrations of luteinising and follicle-stimulating hormones were reduced as well as the responses of these hormones to stimulation with gonadotrophin-releasing hormone. Baseline prolactin concentrations were raised in comparison with those in normal children. The response of prolactin to thyrotrophin-releasing hormone, however, was impaired only in the children who had been receiving the drug for a long time. Phenobarbitone had no effect on the secretion of growth hormone. Further studies should be carried out to ascertain how long these effects on pituitary function last after phenobarbitone is withdrawn and whether this interference with pituitary function modifies the child's subsequent development.
对20名正在使用苯巴比妥预防高热惊厥的男孩，研究了长期使用该药物对垂体对促性腺激素释放激素和促甲状腺激素释放激素反应性的影响。黄体生成素和促卵泡激素的基础浓度降低，同时这些激素对促性腺激素释放激素刺激的反应也降低。与正常儿童相比，催乳素基础浓度升高。然而，只有长期接受该药物治疗的儿童，催乳素对促甲状腺激素释放激素的反应才受损。苯巴比妥对生长激素的分泌没有影响。应进行进一步研究，以确定停用苯巴比妥后这些对垂体功能的影响会持续多久，以及这种对垂体功能的干扰是否会改变儿童随后的发育。
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