Campbell M, Al-Sarraf M
Cancer Treat Rep. 1980 Apr-May;64(4-5):713-5.
A prospective study was carried out to determine the effectiveness and tolerance of ftorafur (2.25 g/m2 daily for 5 days, repeated every 4 weeks) in previously treated patients with advanced squamous cell cancers of the head and neck. Seventeen patients were entered in the study; 15 were evaluable for drug toxicity, and 14 were evaluable for response. Three patients had mild nausea, three had mild-to-moderate lethargy, two had nonspecific generalized weakness, and two had severe stomatitis. Of 15 patients three experienced leukopenia (causing death in one) and four had thrombocytopenia (life-threatening to one). Response to treatment included: progressive disease (nine patients), stable disease (four), and complete response (one with no previous radiotherapy or chemotherapy).
开展了一项前瞻性研究，以确定替加氟（每日2.25 g/m²，连用5天，每4周重复一次）对先前接受过治疗的晚期头颈部鳞状细胞癌患者的有效性和耐受性。17名患者进入该研究；15名可评估药物毒性，14名可评估疗效。3名患者出现轻度恶心，3名出现轻度至中度嗜睡，2名出现非特异性全身无力，2名出现严重口腔炎。15名患者中，3名出现白细胞减少（其中1例导致死亡），4名出现血小板减少（1例危及生命）。治疗反应包括：疾病进展（9例患者）、病情稳定（4例）和完全缓解（1例未接受过放疗或化疗）。
