Miller D J, Dwyer J, Klatskin G
Ann Intern Med. 1978 Aug;89(2):212-5. doi: 10.7326/0003-4819-89-2-212.
Three patients with halothane hepatitis were studied during the acute phase of their illness and for 10 to 14 months thereafter. Clinical, biochemical, and histologic data were obtained initially and during the course of follow-up. Despite initially severe clinical and biochemical presentations, with extensive bridging hepatic necrosis on liver biopsy, all three patients resolved completely and had minimally abnormal liver biopsy appearances at last follow-up. The results of this study suggest that hepatic necrosis associated with halothane hypersensitivity is self-limited and that despite the initial severity of the hepatic lesion, postnecrotic cirrhosis does not develop. Based on these three patients' courses, survival of the acute bout of halothane hepatitis is apparently accompanied by an excellent prognosis ultimately, provided that reexposure to halothane is avoided.
对三名氟烷性肝炎患者在疾病急性期及之后的10至14个月进行了研究。在初始阶段以及随访过程中获取了临床、生化和组织学数据。尽管最初临床和生化表现严重，肝活检显示广泛的桥接性肝坏死，但所有三名患者均完全康复，在最后一次随访时肝活检表现仅有轻微异常。本研究结果表明，与氟烷超敏反应相关的肝坏死是自限性的，尽管肝损伤最初严重，但不会发展为坏死性肝硬化。基于这三名患者的病程，氟烷性肝炎急性期存活者显然最终预后良好，前提是避免再次接触氟烷。
