血清中含κ型球蛋白四聚体的本斯·琼斯骨髓瘤。
Bence Jones myeloma with a tetramer of kappa-type globulin in serum.
作者信息
Gallango M L, Suinaga R, Ramírez M
出版信息
Clin Chem. 1980 Nov;26(12):1741-4.
PMID:6775844
Abstract
We describe a case of Bence Jones multiple myeloma involving two kappa-type monoclonal proteins. One was isolated from serum, the other from both serum and urine. After biochemical and immunochemical analyses, we concluded that one of the proteins was a tetramer, present in serum but not in urine, whereas the other was a monomer, which was excreted in large amounts in the urine during the terminal stage of the disease.
摘要
我们描述了一例伴有两种κ型单克隆蛋白的本斯·琼斯多发性骨髓瘤病例。一种从血清中分离得到，另一种从血清和尿液中均分离得到。经过生化和免疫化学分析，我们得出结论，其中一种蛋白是四聚体，存在于血清中但不存在于尿液中，而另一种是单体，在疾病终末期大量排泄于尿液中。
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