Drude R B, Finkelman D, Davis W D, Ferrante W A
Dig Dis Sci. 1980 Oct;25(10):802-6. doi: 10.1007/BF01345304.
Patients with jejunal diverticula usually are asymptomatic unless bacterial overgrowth within the diverticula is sufficient to cause vitamin B12 deficiency, by direct uptake of the vitamin by the bacteria, or malabsorption resulting from bacterial deconjugation of bile salts and impaired lipid digestion. The administration of broad-spectrum antibiotics usually constitutes effective treatment that suppresses bacterial flora, with surgery reserved for complications such as hemorrhage, perforation, and abscess formation, and acute or chronic intestinal obstruction. Our patient had many diverticula, and two courses of antibiotics failed to provide prolonged relief of symptoms. After surgical exploration to exclude the presence of partial intestinal obstruction or infiltrating disease of the terminal ileum, the segment of jejunum bearing diverticula was resected. Since operation the patient has remained asymptomatic, which suggests that in certain patients, even with many diverticula, surgical exploration and excision of the diverticula may be curative.
空肠憩室患者通常无症状，除非憩室内细菌过度生长足以导致维生素B12缺乏，这种缺乏是由于细菌直接摄取维生素，或因细菌使胆盐解偶联及脂质消化受损而导致吸收不良。使用广谱抗生素通常是有效的治疗方法，可抑制细菌菌群，手术则用于治疗诸如出血、穿孔、脓肿形成以及急性或慢性肠梗阻等并发症。我们的患者有许多憩室，两疗程抗生素治疗未能使症状得到长期缓解。在进行手术探查以排除部分肠梗阻或回肠末端浸润性疾病后，切除了带有憩室的空肠段。自手术以来，患者一直无症状，这表明在某些患者中，即使有许多憩室，手术探查和憩室切除也可能治愈疾病。
