Mukamel E, Zitron S, Nissenkorn I, Servadio C
Isr J Med Sci. 1980 Sep-Oct;16(9-10):714-6.
The prophylactic effect of triethylenethiophosphoramide (thio-TEPA) on the recurrence rate of superficial transitional cell carcinoma of the bladder was examined in three groups of patients. Patients in group 1 had been treated by transurethral resection of the tumor before the study began; thereafter, topical thio-TEPA was added to the therapeutic regimen. The mean recurrence rate in this group dropped from 1 in 11.1 months before treatment with thio-TEPA to 1 in 28.6 months during treatment. Group 2 included patients treated by transurethral resection, with the addition of thio-TEPA instillation as soon as a diagnosis of transitional cell carcinoma of the bladder was established. In this group, the recurrence rate was 1 in 34.6 months. The control group for group 2 (group 3) was treated by transurethral resection of the tumor with no thio-TEPA instillation, and in this group, the recurrence rate was 1 in 11.6 months. These results justify the prophylactic use of thio-TEPA in patients with transitional cell carcinoma of the bladder.
在三组患者中研究了三乙烯硫代磷酰胺（硫替派）对膀胱浅表性移行细胞癌复发率的预防作用。第一组患者在研究开始前已接受经尿道肿瘤切除术；此后，在治疗方案中加入了局部硫替派。该组的平均复发率从硫替派治疗前的每11.1个月1次降至治疗期间的每28.6个月1次。第二组包括经尿道切除术后的患者，一旦确诊膀胱移行细胞癌，即加入硫替派灌注治疗。该组的复发率为每34.6个月1次。第二组的对照组（第三组）仅接受经尿道肿瘤切除术，未进行硫替派灌注，该组的复发率为每11.6个月1次。这些结果证明硫替派可用于预防膀胱移行细胞癌患者的复发。
