Hobbs C L, Mullen J L, Gertner M H, Buzby G P, Rosato E F
JPEN J Parenter Enteral Nutr. 1980 Sep-Oct;4(5):443-5. doi: 10.1177/014860718000400501.
To establish the subhuman primate as an effective laboratory animal in parenteral nutrition research, 18 male macaque monkeys were adapted to chronic chair restraint and maintained on intravenous nutrition for 1- and 2-week periods. The animals remained in the restraint chairs for 11.6 +/- (2.3) weeks and the inferior vena cava catheters remained for 53 +/- (7.8) days. Catheter and metabolic complications during intravenous nutrition infusion were few and morbidity was low. The animals maintained weight, serum albumin, and serum transferrin levels as well as a positive nitrogen balance during the study period. The macaque is a highly suitable model for nutritional studies requiring a controlled environment during long-term studies.
