Hirai Y, Sanada Y, Nakagawa T
JPEN J Parenter Enteral Nutr. 1980 Sep-Oct;4(5):460-3. doi: 10.1177/014860718000400505.
Sixty-nine infants and children with surgical disorders were fed an enteral elemental diet consisting of synthetic L-amino acids, dextroglucose, soybean oil, electrolytes and vitamins. Satisfactory clinical results were achieved in 55 patients, whose average positive nitrogen balance was approximately 578 mg/day in neonates, 1,518 mg/day in infants and 2,452 mg/day in children; average weight gain was approximately 16 g/day in neonates, 23 g/day in infants, and 21 g/day in children during total enteral nutrition with the diet. Elevation of serum transaminase values was noted in 5 patients receiving total enteral nutrition with the diet. Liver toxicity may have been caused by the composition of amino acids of the diet, solely free amino acids as protein component. However, the diet provided a valuable therapeutic alternative to total parenteral nutrition in selected infants and children requiring surgery.
69名患有外科疾病的婴幼儿接受了一种肠内要素饮食,该饮食由合成L-氨基酸、葡萄糖、大豆油、电解质和维生素组成。55名患者取得了满意的临床效果,在接受该饮食进行全肠内营养期间,新生儿的平均正氮平衡约为578毫克/天,婴儿为1518毫克/天,儿童为2452毫克/天;新生儿的平均体重增加约为16克/天,婴儿为23克/天,儿童为21克/天。5名接受该饮食进行全肠内营养的患者出现了血清转氨酶值升高的情况。肝毒性可能是由该饮食的氨基酸组成导致的,其蛋白质成分仅为游离氨基酸。然而,对于某些需要手术的婴幼儿来说,该饮食为全胃肠外营养提供了一种有价值的治疗替代方案。