De Alwis M C, Carter G R
Vet Rec. 1980 May 24;106(21):435-7. doi: 10.1136/vr.106.21.435.
In two trials, 68 cattle and buffalo calves, four to 10 months of age, were vaccinated with a vaccine containing a live streptomycin dependent mutant of Pasteurella multocida type B, isolated in Sri Lanka. Immunity was assessed using the passive protection test in mice with cattle and buffalo sera before and two or three weeks after vaccination. A single dose of vaccine conferred immunity in 66.6 to 83.3 per cent of cattle and 100 per cent of buffalo calves. A booster dose given three weeks later enhanced the immunity in cattle. There was no significant difference in the response, whether the vaccine was administered by the subcutaneous or intramuscular route. No adverse reactions were observed in any of the vaccinated animals.
在两项试验中，给68头4至10月龄的牛犊和水牛犊接种了一种疫苗，该疫苗含有在斯里兰卡分离出的B型多杀巴斯德氏菌的链霉素依赖型活突变株。在接种疫苗前以及接种后两周或三周，使用牛和水牛血清对小鼠进行被动保护试验来评估免疫力。单剂量疫苗使66.6%至83.3%的牛和100%的水牛犊产生了免疫力。三周后给予加强剂量增强了牛的免疫力。无论疫苗是通过皮下还是肌肉注射途径给药，反应均无显著差异。在任何接种疫苗的动物中均未观察到不良反应。
