Medina M, Ulloa-Aguirre A, Fernández M A, Pérez-Palacios G
Acta Endocrinol (Copenh). 1980 Nov;95(3):314-8. doi: 10.1530/acta.0.0950314.
The role of oestrogens on gonadotrophin secretion was assessed in three related patients with the complete form of testicular feminization syndrome. Serum LH and FSH levels were measured before and after LRH stimulation as well as before, during and after chronic clomiphene citrate administration. Moderately elevated LH basal levels with a significant LH rise following LRH were observed. Normal or even low FSH level with poor response to LRH were found in all subjects. Administration of clomiphene citrate resulted in a significant serum LH increase without any change of FSH. Following castration both LH and FSH rose and a normal response to LRH was observed. These results were interpreted as demonstrating that, while endogenous oestrogens modulate LH secretion in patients with androgen unresponsiveness, it plays no role in regulating FSH secretion and suggested that a factor of testicular origin without androgenic or oestrogenic activity is responsible for FSH regulation.
在三名患有完全型睾丸女性化综合征的相关患者中评估了雌激素对促性腺激素分泌的作用。在促黄体生成素释放激素（LRH）刺激前后以及在长期服用枸橼酸氯米芬之前、期间和之后测量血清促黄体生成素（LH）和促卵泡生成素（FSH）水平。观察到基础LH水平中度升高，LRH刺激后LH显著升高。在所有受试者中发现FSH水平正常甚至偏低，对LRH反应不佳。服用枸橼酸氯米芬导致血清LH显著增加，而FSH无任何变化。阉割后LH和FSH均升高，并且观察到对LRH的正常反应。这些结果被解释为表明，虽然内源性雌激素调节雄激素无反应患者的LH分泌，但它在调节FSH分泌中不起作用，并提示一种无雄激素或雌激素活性的睾丸源性因子负责FSH的调节。
