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通过血浆置换和免疫抑制治疗联合控制一名患有抑制物的血友病患者的危及生命的出血。

Control of life-threatening bleeding by combined plasmapheresis and immunosuppressive treatment in a haemophiliac with inhibitors.

作者信息

Révész T, Mátyus J, Goldschmidt B, Harsanyi V

出版信息

Arch Dis Child. 1980 Aug;55(8):641-3. doi: 10.1136/adc.55.8.641.

DOI:10.1136/adc.55.8.641
PMID:6776907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1627031/
Abstract

Life-threatening lingual haemorrhage was successfully treated in a 3-year-old haemophiliac who had a high level of inhibitor in his plasma. Repeated plasma exchange with high-dose factor VIII concentrate led to a cessation of bleeding. Immunosuppressive treatment introduced at the time of plasmapheresis and carried out for 6 weeks seems to have prevented the return of the inhibitor.

摘要

一名3岁血浆中抑制剂水平较高的血友病患者的危及生命的舌部出血得到了成功治疗。反复进行高剂量凝血因子VIII浓缩物的血浆置换导致出血停止。在血浆置换时引入并进行6周的免疫抑制治疗似乎防止了抑制剂的再次出现。

相似文献

1
Control of life-threatening bleeding by combined plasmapheresis and immunosuppressive treatment in a haemophiliac with inhibitors.通过血浆置换和免疫抑制治疗联合控制一名患有抑制物的血友病患者的危及生命的出血。
Arch Dis Child. 1980 Aug;55(8):641-3. doi: 10.1136/adc.55.8.641.
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Plasma exchange and human factor VIII concentrate in managing haemophilia A with factor VIII inhibitors.血浆置换和人凝血因子VIII浓缩物在治疗伴有凝血因子VIII抑制剂的甲型血友病中的应用
Br Med J. 1980 Nov 22;281(6252):1388-9. doi: 10.1136/bmj.281.6252.1388.
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Hemophilia with factor VIII and factor IX inhibitors, incidence, bleeding problems and management.伴有因子VIII和因子IX抑制剂的血友病、发病率、出血问题及管理
Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:106-12.
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[Treatment of haemorrhages in a haemophiliac with factor-VIII inhibitor (author's transl)].
Dtsch Med Wochenschr. 1979 Feb 2;104(5):182-6. doi: 10.1055/s-0028-1103867.
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Plasmapheresis: its value in the management of patients with antibodies to factor VIII.
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Serial plasmapheresis in a haemophiliac with antibodies to FVIII.对血友病A伴抗FVIII抗体患者进行连续血浆置换术。
J Clin Pathol. 1977 Aug;30(8):763-5. doi: 10.1136/jcp.30.8.763.
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Life-threatening oro-pharyngeal bleeding in a haemophiliac with factor VIII inhibitors.一名患有VIII因子抑制剂的血友病患者出现危及生命的口咽出血。
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JAMA. 1984 Nov 16;252(19):2726-9.
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Ther Apher. 1999 Nov;3(4):320-2. doi: 10.1046/j.1526-0968.1999.00208.x.

引用本文的文献

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Current options and new developments in the treatment of haemophilia.血友病治疗的现有选择和新进展。
Drugs. 2011 Feb 12;71(3):305-20. doi: 10.2165/11585340-000000000-00000.

本文引用的文献

1
Immunosuppressive treatment in haemophiliacs with inhibitors to factor VIII and factor IX.对患有VIII因子和IX因子抑制物的血友病患者进行免疫抑制治疗。
Scand J Haematol. 1976 May;16(5):369-82. doi: 10.1111/j.1600-0609.1976.tb00330.x.
2
Disseminated intravascular coagulation and infusion of factor-VIII-inhibitor bypassing activity.
Lancet. 1977 Feb 12;1(8007):360. doi: 10.1016/s0140-6736(77)91156-4.
3
Letter: Prothrombin-complex concentrate in treatment of classical haemophilia with factor-VIII antibody.
Lancet. 1975 Dec 13;2(7946):1203. doi: 10.1016/s0140-6736(75)92683-5.