黑腹果蝇异染色质的遗传分析。

The genetic analysis of D. melanogaster heterochromatin.

作者信息

Hilliker A J, Appels R, Schalet A

出版信息

Cell. 1980 Oct;21(3):607-19. doi: 10.1016/0092-8674(80)90424-9.

Abstract

Classical, or constitutive (Brown, 1966), heterochromatin is a nearly ubiquitous aspect of higher eukaryotic chromosome structure and its genetic significance has been debated since its first description (Heitz, 1928, 1929). This review describes genetic studies on the heterochromatin of Drosophila and the perspectives they provide on the possible biological role(s) of constitutive heterochromatin. In addition to documenting the existence of gene loci within heterochromatin, these studies provide evidence for long-range interactions within the nucleus and involving heterochromatin. These interactions may reflect more general properties of chromatin related to the three-dimensional structure of the interphase nucleus and its effects on gene expression.

摘要

经典的，即组成型（布朗，1966年）异染色质，是高等真核生物染色体结构几乎普遍存在的一个方面，自其首次被描述以来（海茨，1928年，1929年），其遗传学意义一直存在争议。本综述描述了对果蝇异染色质的遗传学研究以及它们对组成型异染色质可能的生物学作用所提供的观点。除了记录异染色质内基因座的存在外，这些研究还为细胞核内涉及异染色质的长程相互作用提供了证据。这些相互作用可能反映了与间期细胞核三维结构及其对基因表达影响相关的染色质更普遍的特性。