Knoblich O E, Spatz R, Drasch G, Anemueller N
EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1980 Jun;11(2):102-6.
With bromism we stated a slow EEG-activity. Such alterations of the electro-encephalogram can be caused by urea of bromine, its metabolites and by the inorganic bromide ion. We tried to find out the real effect of the bromide ion which is not bound in the serum. Therefore we only examined the EEG and the bromine serum after the acute influence of the urea of bromine had faded (> 5 days). Patients suffering of disturbances of metabolism or system-diseases, tumors and infections or patients undergoing a medicamentous therapy were excluded from these tests. During the years 1971, 1972 and 1977 we found 26 patients (bromine in serum > 5 mg%) who corresponded to the above mentioned conditions and on whose data the results of our studies are based. 16 patients had very high bromine values (> 24,6 mg%). Most of these patients (10 out of 16) showed paranoid-hallucinatory symptoms. We also stated delirious and depressive attacks. No one suffered of mental dullness. The EEG of 7 patients showed general alterations. With lower bromine values (< 24,6 mg%) we could neither state general alterations of the EEG nor psychotic or delirious symptoms. We didn't observe any paroxysmal disturbance of the EEG. We also didn't notice a acceleration of the EEG, as it was stated with other medical preparations.
对于溴中毒患者，我们发现其脑电图（EEG）活动缓慢。脑电图的这种改变可能由溴化脲、其代谢产物以及无机溴离子引起。我们试图找出未与血清结合的溴离子的实际作用。因此，我们仅在溴化脲的急性影响消退后（>5天）检查脑电图和血清溴含量。患有代谢紊乱或系统性疾病、肿瘤和感染的患者或正在接受药物治疗的患者被排除在这些测试之外。在1971年、1972年和1977年期间，我们发现26例患者（血清溴含量>5mg%）符合上述条件，我们的研究结果基于这些患者的数据。16例患者的溴含量非常高（>24.6mg%）。这些患者中的大多数（16例中的10例）表现出偏执幻觉症状。我们还发现了谵妄和抑郁发作。没有人患有智力迟钝。7例患者的脑电图显示出总体改变。溴含量较低（<24.6mg%）时，我们既未发现脑电图的总体改变，也未发现精神病性或谵妄症状。我们未观察到脑电图的任何阵发性紊乱。我们也未注意到脑电图加速，其他药物制剂曾有过这种情况。
