Lee P A, Hogan M J
Growth. 1980 Jun;44(2):147-51.
In order to evaluate possible abnormalities among males with constitutional delay of growth and adolescence, hormonal responses and interrelationships have been extensively evaluated in a young man with a documented history of this condition and compared with young men with a history of normal puberty as controls. Normal hypothalamic-pituitary sensitivity to circulating sex steroids and a normal end-organ response (nitrogen and phosphorus retention) to testosterone stimulation were found. There was, however, a decreased gonadal (testosterone) response to gonadotropin (HCG) stimulation and a decreased pituitary response to clomiphene stimulation. These decreased responses could explain the observed adolescent delay in growth and maturation observed in these individuals.
为了评估体质性生长和青春期延迟男性可能存在的异常情况，对一名有该病症记录病史的年轻男性的激素反应及相互关系进行了广泛评估，并与有正常青春期病史的年轻男性作为对照进行比较。发现下丘脑 - 垂体对循环性激素具有正常敏感性，且终末器官对睾酮刺激有正常反应（氮和磷潴留）。然而，性腺（睾酮）对促性腺激素（人绒毛膜促性腺激素）刺激的反应降低，垂体对克罗米芬刺激的反应也降低。这些降低的反应可以解释在这些个体中观察到的青春期生长和成熟延迟现象。
