Hashimoto J M, Epstein D L
Invest Ophthalmol Vis Sci. 1980 Dec;19(12):1483-9.
Freshly enucleated monkey, calf, and human eyes were quantitatively perfused with mock aqueous humor through the anterior chamber by a constant pressure technique. After baseline perfusion at 15 mm Hg, intraocular pressure was raised to 45 mm Hg and later reduced back to 15 mm Hg. Calf and human (both adult and infant) eyes had lower outflow facilities at 45 than at 15 mm Hg. However, four types of monkey eyes did not show decreased facility of outflow at elevated perfusion pressure, and after return of pressure to 15 mm Hg, facility of outflow actually increased compared to baseline, unlike both calf and human eyes. The results indicate that there are significant differences in the response of enucleated mammalian eyes to an elevation in perfusion pressure. Factors other than, or in addition to, collapse of Schlemm's canal may be important in the pathogenesis of the pressure-induced decrease in outflow facility found in human eyes.
通过恒压技术，将模拟房水经前房定量灌注到刚摘除的猴眼、小牛眼和人眼。在15毫米汞柱的基线灌注后，眼内压升至45毫米汞柱，随后又降至15毫米汞柱。小牛眼和人眼（成人和婴儿）在45毫米汞柱时的房水流出率低于15毫米汞柱时。然而，四种类型的猴眼在灌注压升高时并未表现出房水流出率降低，并且在压力恢复到15毫米汞柱后，与基线相比，房水流出率实际上增加了，这与小牛眼和人眼不同。结果表明，摘除的哺乳动物眼对灌注压升高的反应存在显著差异。在人眼中发现的压力诱导的房水流出率降低的发病机制中，除了施莱姆管塌陷之外或之外的其他因素可能很重要。
