Poppema S
J Histochem Cytochem. 1980 Aug;28(8):788-91. doi: 10.1177/28.8.6777426.
Lymph node tissue of eight cases of Hodgkin's disease of all different subtypes was studied with an immunoperoxidase technique for the detection of immunoglobulin G (IgG), J chain, kappa and lambda light chains, and alpha-1-antitrypsin in different types of Sternberg-Reed cells. It was found that L&H type Sternberg-Reed cells of the nodular lymphocyte predominance type contained IgG, J chain, and one type of light chain per individual cell. It is concluded that these findings indicate that L&H type Sternberg-Reed cells produce IgG and, consequently, are B immunoblasts. Typical and lacunar type Sternberg-Reed cells of mixed cellularity and nodular sclerosis subtypes were found to contain IgG and both types of light chains per individual cell. J chain was absent from these cells are alpha-1-antitrypsin was found in some of them in a paranuclear pattern, comparable to that in histiocytes. It is concluded that these findings exclude the production of IgG by these types of Sternberg-Reed cells and it is suggested that these Sternberg-Reed cells may be related to histiocytes on the basis of the similarity in the staining pattern for alpha-1-antitrypsin.
运用免疫过氧化物酶技术，对8例不同亚型霍奇金病的淋巴结组织进行研究，以检测不同类型的施特恩伯格-里德（Sternberg-Reed）细胞中的免疫球蛋白G（IgG）、J链、κ和λ轻链以及α1抗胰蛋白酶。结果发现，结节性淋巴细胞为主型的L&H型施特恩伯格-里德细胞每个细胞都含有IgG、J链和一种轻链。由此得出结论，这些发现表明L&H型施特恩伯格-里德细胞产生IgG，因此是B免疫母细胞。混合细胞型和结节硬化型的典型和陷窝型施特恩伯格-里德细胞每个细胞都含有IgG和两种轻链。这些细胞中没有J链，部分细胞中发现α1抗胰蛋白酶呈核旁模式，与组织细胞中的模式相似。由此得出结论，这些发现排除了这些类型的施特恩伯格-里德细胞产生IgG的可能性，并基于α1抗胰蛋白酶染色模式的相似性，提示这些施特恩伯格-里德细胞可能与组织细胞有关。
