Yajima A, Higashiiwai H, Sato A, Watanabe M, Mori T, Suzuki M, Hanyu T, Suzuki K, Kinii H, Moritsuka T, Igarashi N, Nakano M, Nagasawa K, Sato S
Tohoku J Exp Med. 1980 Oct;132(2):225-9. doi: 10.1620/tjem.132.225.
Among the 95 cases of ovarian cancer treated by us between May, 1975 and August, 1978, only 33 were suitable for complete resection. The remaining 62 cases underwent incomplete resection, followed by F.Q.C. combination chemotherapy (1-(2-tetrahydrofuryl)-5-fluorouracil, carbazilquinone, cytosine arabinoside); 54.8% showed an antitumor response. The median survival time of the responders was 13.2 months, whereas it was 7.4 months for the non-responders. The survival rate after 24 months, however, was 13% and 4%, respectively. Side effects of the drugs, including leucopenia, thrombocytopenia, nausea and vomiting, were found in roughly one half of the cases.
在我们于1975年5月至1978年8月期间治疗的95例卵巢癌患者中，只有33例适合进行根治性切除。其余62例接受了不完全切除，随后进行F.Q.C.联合化疗（1-(2-四氢呋喃基)-5-氟尿嘧啶、卡巴醌、阿糖胞苷）；54.8%的患者显示出抗肿瘤反应。有反应者的中位生存时间为13.2个月，而无反应者为7.4个月。然而，24个月后的生存率分别为13%和4%。约一半的病例出现了包括白细胞减少、血小板减少、恶心和呕吐在内的药物副作用。
