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受感染红细胞上的疟原虫抗原。

Malarial antigens on infected erythrocytes.

作者信息

Vincent H M, Wilson R J

出版信息

Trans R Soc Trop Med Hyg. 1980;74(4):452-5. doi: 10.1016/0035-9203(80)90052-8.

DOI:10.1016/0035-9203(80)90052-8
PMID:6777912
Abstract

Absorption experiments with washed membranes derived from erythrocytes infected with schizonts of Plasmodium knowlesi (PE) showed that the antigen responsible for agglutination of PE in SICA tests is firmly bound to membranes. Further experiments demonstrated that the number of antibody binding sites at the surface of parasitized erythrocytes can be measured using iodinated globulins. The conditions under which this could be achieved have been defined and a preliminary estimate of the number of high affinity surface antigen sites (greater than or equal to 10(4) per cell) has been made. Suggestions are given for further work to obtain a more accurate value.

摘要

用感染诺氏疟原虫裂殖体的红细胞(PE)来源的洗涤膜进行的吸收实验表明,在SICA试验中导致PE凝集的抗原与膜紧密结合。进一步的实验证明,可以使用碘化球蛋白来测量被寄生红细胞表面的抗体结合位点数量。已经确定了实现这一点的条件,并对高亲和力表面抗原位点的数量(每个细胞大于或等于10⁴)进行了初步估计。文中给出了进一步工作的建议,以获得更准确的值。

相似文献

1
Malarial antigens on infected erythrocytes.受感染红细胞上的疟原虫抗原。
Trans R Soc Trop Med Hyg. 1980;74(4):452-5. doi: 10.1016/0035-9203(80)90052-8.
2
Splenic requirement for antigenic variation and expression of the variant antigen on the erythrocyte membrane in cloned Plasmodium knowlesi malaria.克隆疟原虫诺氏疟原虫疟疾中脾脏对抗原变异的需求以及变异抗原在红细胞膜上的表达
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3
Antigenic variation of Plasmodium knowlesi malaria: identification of the variant antigen on infected erythrocytes.诺氏疟原虫疟疾的抗原变异:感染红细胞上变异抗原的鉴定。
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Altered expression of Plasmodium knowlesi variant antigen on the erythrocyte membrane in splenectomized rhesus monkeys.诺氏疟原虫变异抗原在脾切除恒河猴红细胞膜上的表达改变
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Influence of the spleen on the expression of surface antigens on parasitized erythrocytes.脾脏对被寄生红细胞表面抗原表达的影响。
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Cytoadhesion Involves SICA Variant Proteins.细胞黏附涉及 SICA 变体蛋白。
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Immunochemical analysis of surface membrane antigens on erythrocytes infected with non-cloned SICA[+] or cloned SICA[-] Plasmodium knowlesi.对感染非克隆的SICA[+]或克隆的SICA[-]诺氏疟原虫的红细胞表面膜抗原进行免疫化学分析。
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Plasmodium knowlesi-induced antigens in membranes of parasitized rhesus monkey erythrocytes.诺氏疟原虫诱导的恒河猴寄生红细胞膜抗原。
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Antibodies in malarial sera to parasite antigens in the membrane of erythrocytes infected with early asexual stages of Plasmodium falciparum.疟疾血清中针对恶性疟原虫早期无性阶段感染的红细胞膜内寄生虫抗原的抗体。
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Trans Assoc Am Physicians. 1986;99:206-13.

引用本文的文献

1
Placental pathologic changes in malaria. A histologic and ultrastructural study.疟疾中的胎盘病理变化。一项组织学和超微结构研究。
Am J Pathol. 1982 Dec;109(3):330-42.
2
An intracellular simian malarial parasite (Plasmodium knowlesi) induces stage-dependent alterations in membrane phospholipid organization of its host erythrocyte.一种细胞内猿疟原虫(诺氏疟原虫)会诱导其宿主红细胞膜磷脂组织发生阶段依赖性改变。
Biochem J. 1987 Aug 15;246(1):103-8. doi: 10.1042/bj2460103.