Geyer G, Linss W
Acta Histochem. 1980;67(1):76-9. doi: 10.1016/S0065-1281(80)80056-0.
Contrary to the rather high amount of acetylcholine esterase, histochemical methods revealed only an insignificant activity of that enzyme in the erythrocyte plasmalemma. Following hypotonic incubation many damaged red cells whether or not hemolyzed were heavily loaded with reaction products on the outer aspect of their membrane. The findings are consistent with a suggested allosteric activation of acetylcholine esterase in the moderately disintegrated cell membrane. Thus, the cytochemical demonstration of acetylcholine esterase is considered a means to assess the plasmalemmal integrity of individual red cells.
与乙酰胆碱酯酶含量相当高的情况相反，组织化学方法显示该酶在红细胞质膜中的活性微不足道。低渗孵育后，许多受损的红细胞，无论是否发生溶血，其膜外侧都大量负载有反应产物。这些发现与中度解体细胞膜中乙酰胆碱酯酶的变构激活假说一致。因此，乙酰胆碱酯酶的细胞化学显示被认为是评估单个红细胞质膜完整性的一种手段。
