Cavaillon J M, Bona C, Staub A M
Ann Immunol (Paris). 1978 Feb-Mar;129(2-3):199-213.
Following immunization with bacteria (i.e. Salmonella johannesburg), rabbit spleen lymphocytes developed a specific blast response when the lymphocytes were stimulated with polysaccharide, the haptenic moiety of lipopolysaccharide. A clear cut dissociation was noted in the blast response induced by polysaccharide compared with those induced by lipopolysaccharide and lipid A. There was no correlation between the magnitude of the cellular responses and that of the antibody response. Moreover, there was less specificity at the cellular level than at the level of antibody secreted by cells. A decrease of 3H-thymidine incorporation was often observed after immunization, at the level of peripheral blood lymphocytes. An inhibitory effect of these cells was shown on the blast response of spleen lymphocytes with polysaccharide. A high blast response to Salmonella polysaccharide which could be observed in some non-immunized rabbits might be related to a natural sensitization of animals with the same or related unknown antigens which could not be recognized by anti-S. johannesburg antibodies.
用细菌（即约翰内斯堡沙门氏菌）免疫后，当兔脾淋巴细胞受到脂多糖的半抗原部分多糖刺激时，会产生特异性的母细胞化反应。与脂多糖和脂质A诱导的母细胞化反应相比，多糖诱导的母细胞化反应存在明显的解离现象。细胞反应的强度与抗体反应的强度之间没有相关性。此外，细胞水平的特异性低于细胞分泌抗体的水平。免疫后，在外周血淋巴细胞水平经常观察到3H-胸腺嘧啶核苷掺入量的减少。这些细胞对多糖刺激的脾淋巴细胞的母细胞化反应具有抑制作用。在一些未免疫的兔子中观察到的对沙门氏菌多糖的高母细胞化反应，可能与动物对相同或相关未知抗原的天然致敏有关，而这些抗原不能被抗约翰内斯堡沙门氏菌抗体识别。
