Ginsberg M D, Budd M W, Welsh F A
Ann Neurol. 1978 Jun;3(6):482-92. doi: 10.1002/ana.410030605.
The effects of severe cerebral ischemia on postischemic brain perfusion were examined in a series of pentobarbital-anesthetized cats. Ischemia of 15 or 30 minutes' duration was produced by occlusion of both common carotid arteries and the basilar artery and was coupled with mild systemic hypotension. A 90-minute period of normotensive postischemic recirculation was permitted in some animals. In 9 of 10 animals studied at the end of the ischemic insult and not allowed to recover, blood flow in the cerebral hemispheres was greatly reduced, with minimal flow (0.01 to 0.11 ml gm-1 min-1) persisting only in scattered perisulcal regions in 4 animals. Following 15 minutes of ischemia, blood flow was restored uniformly during recirculation, though at subnormal levels (31 to 35% of control). In contrast, 30 minutes of prior ischemia led to marked heterogeneities of local cerebral perfusion during recirculation, with multiple zones of persistent severe ischemia. Thus, while recirculation was suboptimal following both 15 and 30 minutes of ischemia, the 30-minute insult led to focal postischemic perfusion abnormalities that were sufficiently severe to make the possibility of functional recovery appear unlikely.
在一系列戊巴比妥麻醉的猫中，研究了严重脑缺血对缺血后脑灌注的影响。通过阻断双侧颈总动脉和基底动脉并伴有轻度全身性低血压，造成持续15或30分钟的缺血。部分动物在缺血后进行了90分钟的正常血压再灌注。在缺血损伤结束时进行研究且未允许恢复的10只动物中，有9只动物脑半球的血流大幅减少，只有4只动物在散在的脑沟周围区域存在最低限度的血流（0.01至0.11毫升·克⁻¹·分钟⁻¹）。缺血15分钟后，再灌注期间血流均匀恢复，尽管处于低于正常的水平（为对照的31%至35%）。相比之下，先前30分钟的缺血导致再灌注期间局部脑灌注明显不均一，出现多个持续严重缺血区域。因此，虽然缺血15分钟和30分钟后再灌注都不理想，但30分钟的损伤导致局灶性缺血后灌注异常，严重到使功能恢复的可能性似乎不大。
