O'Shea J S, Langenbrunner D J, McCloskey D E, Pezzullo J C, Regan J B
Ann Otol Rhinol Laryngol Suppl. 1980 May-Jun;89(3 Pt 2):285-9. doi: 10.1177/00034894800890s367.
Fifty-five children with their first recognized episodes of serous otitis media were followed over a three-month period. The efficacy of an antihistamine-adrenergic combination (diphenhydramine and pseudoephedrine), the comparative value of various diagnostic studies of middle ear function, and the prognostic importance of information obtained at the first visit were assessed. Compared double-blindly to a placebo, the pharmaceutical preparations did not appear to influence the clinical course, although more drug patients experienced lethargy or relief of symptoms not directly concerned with middle ear function (mainly upper respiratory congestion). The color and extent of motility of the tympanic membrane, but no other pneumatic otoscopic findings, were related to audiometry, whereas tympanometry correlated with the amount of motility and the presence or absence of visible fluid behind the membrane. The patients with the most severe hearing losses or with visible middle ear fluid at their initial visits improved the most, and those who began to be followed in the summer the least. The last finding may be due to a general but unexplained deterioration of childhood serous otitis media during the fall.
55名首次确诊为浆液性中耳炎的儿童接受了为期三个月的随访。评估了抗组胺药 - 肾上腺素能组合（苯海拉明和伪麻黄碱）的疗效、中耳功能各种诊断研究的比较价值以及首次就诊时所获信息的预后重要性。与安慰剂进行双盲比较时，药物制剂似乎并未影响临床病程，不过更多服用药物的患者出现了嗜睡或与中耳功能无直接关联的症状缓解（主要是上呼吸道充血）。鼓膜活动的颜色和程度与听力测定相关，但其他鼓气耳镜检查结果无关，而鼓室图与活动量以及鼓膜后可见液体的有无相关。首次就诊时听力损失最严重或中耳有可见液体的患者改善最大，而夏季开始随访的患者改善最小。最后这一发现可能是由于秋季儿童浆液性中耳炎普遍但原因不明的病情恶化。
