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抗生素美莫霉素(LIA - 0775)的化学特性

[Chemical characteristics of the antibiotic, memomycin (LIA-0775)].

作者信息

Shenin Iu D, Omel'chenko V N, Onoprienko V V

出版信息

Antibiotiki. 1978 Jul;23(7):582-5.

PMID:677845
Abstract

By its physico-chemical and biological properties memomycin was classified as belonging to the group of hydrostatin-nifimycin. Memomycin contained ester (or lactone) and amide, 7 C-methyl and 10-12 acetylating groups. Oxidation of the antibiotic with an excess of alkaline permanganate solution revealed the presence of an unbroken chain consisting at least of 8 methylen groups in the carbon skeleton of memomycin. Acid hydrolysis revealed no sugars and ninhidrine-positive components. Memomycin differed from the antibiotics close to nifimycin mainly in the UV-spectra. It differed from hydrostatin, muzarine, rinamycin and azalomycin by a complete set of physico-chemical properties and biological spectrum. On the basis of these data memomycin may be considered an original antibiotic.

摘要

根据其物理化学和生物学特性,膜霉素被归类为氢化他汀-尼菲霉素类。膜霉素含有酯(或内酯)和酰胺、7个C-甲基和10 - 12个乙酰化基团。用过量碱性高锰酸钾溶液氧化该抗生素,结果表明膜霉素碳骨架中存在至少由8个亚甲基组成的不间断链。酸水解未发现糖和茚三酮阳性成分。膜霉素与接近尼菲霉素的抗生素主要在紫外光谱方面存在差异。它在一整套物理化学性质和生物谱方面与氢化他汀、穆扎林、利那霉素和氮霉素不同。基于这些数据,膜霉素可被视为一种新型抗生素。

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