降血糖磺脲类药物对兔心脏的电生理效应

Electrophysiological effects of hypoglycaemic sulphonylureas on rabbit heart.

作者信息

Pogátsa G, Németh M

出版信息

Eur J Pharmacol. 1980 Oct 31;67(4):333-8. doi: 10.1016/0014-2999(80)90173-9.

Abstract

The hypoglycaemic sulphonylurea drugs glibenclamide and carbutamide were compared as to their influence on the electrical activity of isolated rabbit heart preparations. Carbutamide (10(-5)-10(-3) M) was found to depress slightly the nomotopic and junctional automaticity, while in Purkinje fibres it enhanced automaticity and conduction velocity. On the other hand, glibenclamide (10(-6)-10(-3) M) had no significant influence on the nomotopic and junctional automaticity, and markedly depressed automaticity and conduction velocity in the Purkinje fibres. The atrial conduction system was not much influenced by the sulphonylureas tested. Carbutamide depressed the electrical threshold in Purkinje fibres. It follows that the hypoglycaemic sulphonylurea compounds carbutamide and glibenclamide differ considerably with respect to their influences on cardiac electrical activity.

摘要

对降血糖磺酰脲类药物格列本脲和卡比马脲对离体兔心脏标本电活动的影响进行了比较。发现卡比马脲（10⁻⁵ - 10⁻³ M）对正常节律性和交界性自律性有轻微抑制作用，而在浦肯野纤维中它增强了自律性和传导速度。另一方面，格列本脲（10⁻⁶ - 10⁻³ M）对正常节律性和交界性自律性无显著影响，且明显降低了浦肯野纤维的自律性和传导速度。所测试的磺酰脲类药物对心房传导系统影响不大。卡比马脲降低了浦肯野纤维的电阈值。由此可见，降血糖磺酰脲类化合物卡比马脲和格列本脲对心脏电活动的影响有很大差异。