Austic R E, Calvert C C
Fed Proc. 1981 Jan;40(1):63-7.
Evidence for interactions between amino acid and electrolyte metabolism is reviewed. Variations in dietary sodium, potassium, and chloride concentrations affect acid-base balance and also influence the severity of the lysine-arginine antagonism. High dietary levels of Na and K salts of metabolizable organic acids alleviate, whereas excessive dietary chloride exacerbates, the antagonism. Potassium deficiency causes depletion of intracellular potassium and increased intracellular accumulation of basic amino acids. These variations in electrolytes, which alter acid-base balance, also influence the metabolism of glutamic acid and the excretion of nitrogen. It is hypothesized that basic amino acids as well as glutamic acid and glutamine may have an important role in metabolic regulation of acid-base balance.
本文综述了氨基酸与电解质代谢之间相互作用的证据。膳食中钠、钾和氯浓度的变化会影响酸碱平衡，也会影响赖氨酸 - 精氨酸拮抗作用的严重程度。可代谢有机酸的高膳食水平的钠盐和钾盐可缓解拮抗作用，而过量的膳食氯则会加剧这种拮抗作用。钾缺乏会导致细胞内钾的消耗以及碱性氨基酸在细胞内的积累增加。这些改变酸碱平衡的电解质变化也会影响谷氨酸的代谢和氮的排泄。据推测，碱性氨基酸以及谷氨酸和谷氨酰胺可能在酸碱平衡的代谢调节中起重要作用。
