Previtali M, Salerno J A, Falcone C, Lepore R, Chimienti M, Medici A, Angoli L, Bobba P
G Ital Cardiol. 1980;10(5):584-91.
The effect on exercise tolerance of nitroglycerin (NTG) ointment was studied by exercise test on bicycle ergometer in a selected group of patients with effort angina and angiographically proven critical coronary lesions. NTG ointment (15 mg) and placebo were administered in a double-blind cross-over randomized trial on two consecutive days; exercise test was carried out before the administration of NTG ointment and placebo, and repeated after one hour, 2 and 1/2 hours and 4 hours. Compared to control and placebo tests, NTG ointment produced a highly significant increase of duration of exercise and of total work load in all tests, as well as a significant decrease of maximal ST segment depression. After NTG ointment administration resting systolic blood pressure showed a significant decrease after one hour, 2 and 1/2 hours and 4 hours, resting heart rate a significant increase after 2 and 1/2 and 4 hours, and peak exercise heart rate a significant increase after 4 hours. Double product at rest was unaffected by NTG ointment, while at peak exercise it showed a significant increase only after 4 hours. Our data show that in patients with effort angina NTG ointment produces an important increase of exercise capacity which persists at least for 4 hours after the administration. Therefore NTG ointment seems to be of high value in the treatment of effort angina.
在一组经血管造影证实有严重冠状动脉病变的劳力性心绞痛患者中，通过自行车测力计运动试验研究了硝酸甘油（NTG）软膏对运动耐量的影响。在一项双盲交叉随机试验中，连续两天给予NTG软膏（15毫克）和安慰剂；在给予NTG软膏和安慰剂之前进行运动试验，并在1小时、2.5小时和4小时后重复进行。与对照和安慰剂试验相比，NTG软膏在所有试验中均使运动持续时间和总工作量显著增加，同时使最大ST段压低显著降低。给予NTG软膏后，静息收缩压在1小时、2.5小时和4小时后显著降低，静息心率在2.5小时和4小时后显著增加，运动峰值心率在4小时后显著增加。静息时的双乘积不受NTG软膏影响，而在运动峰值时仅在4小时后显著增加。我们的数据表明，在劳力性心绞痛患者中，NTG软膏可显著提高运动能力，且给药后至少持续4小时。因此，NTG软膏似乎在劳力性心绞痛的治疗中具有很高的价值。
