Lee S, Chandler J G, Broelsch C E, Ehara Y, Condon J K, Charters A C, Yen S S, Orloff M J
J Microsurg. 1980 May-Jun;1(6):440-6. doi: 10.1002/micr.1920010606.
When the livers of female rats were provided with exclusive first access to all ovarian venous effluents by simultaneous castration and implantation of a portion of one of the ovaries beneath the splenic capsule, systemic venous plasma concentrations of estrone and estradiol were reduced 40%. Paradoxically, progestins in the peripheral plasma increased threefold, most probably because of augmented adrenocortical progestin secretion. Nevertheless, the change in estrogen levels alone was sufficient to abolish trophic effects on the genital organs and to block normal inhibition of pituitary gonadotropin secretion. Plasma gonadotropin concentrations were markedly elevated to levels comparable to those of castrates, and, as a result, the intrasplenic ovarian implants grew excessively and became histologically disorganized. A patent portacaval shunt negated the entire process, providing proof that the measured hormonal alterations and the change in the implant itself were direct consequences of hepatic screening.
当通过同时切除卵巢并将一侧卵巢的一部分植入脾包膜下，使雌性大鼠的肝脏首先获得所有卵巢静脉流出物时，雌酮和雌二醇的全身静脉血浆浓度降低了40%。矛盾的是，外周血浆中的孕激素增加了两倍，很可能是由于肾上腺皮质孕激素分泌增加。然而，仅雌激素水平的变化就足以消除对生殖器官的营养作用，并阻止垂体促性腺激素分泌的正常抑制。血浆促性腺激素浓度显著升高至与去势动物相当的水平，结果，脾内卵巢植入物过度生长并在组织学上变得紊乱。一条开放的门腔分流术使整个过程无效，这证明所测量的激素变化和植入物本身的变化是肝脏筛选的直接结果。
