Krutchkoff D, James R
Arch Dermatol. 1978 Aug;114(8):1203-6. doi: 10.1001/archderm.114.8.1203.
Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained in our case with local triamcinolone acetonide injections and surgery. Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a seris of triamcinolone injections. It was found that the injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect of granulomas with subsequent replacement by fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a second cheiloplastic procedure. We therefore recommended that patients with chelitis granulomatosa who are receiving combinaed triamcinolone-surgical therapy continue to receive local triamcinolone injections after surgery in order to minimize the tendency for recurrence.
肉芽肿性唇炎是一种罕见的疾病，传统上已证明难以得到令人满意的治疗。在我们的病例中，通过局部注射曲安奈德和手术取得了良好的效果。回顾了典型的未经治疗的疾病的组织病理学特征，并将其与一系列曲安奈德注射后唇部组织的组织病理学特征进行了比较。结果发现，注射的药物通过肉芽肿的坏死作用以及随后被纤维瘢痕替代，有效地减少了唇部体积。初次手术后停止局部注射显然导致了病情加重，这在第二次唇部整形手术的组织病理学中得到了体现。因此，我们建议接受曲安奈德 - 手术联合治疗的肉芽肿性唇炎患者在术后继续接受局部曲安奈德注射，以尽量减少复发的倾向。
