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水杨酸钠(2.5M)致肾上腺髓质化学性硬化——组织病理学、组织酶学、电子显微镜及生物化学研究

Chemical sclerosis of the adrenal medulla with sodium salyclate (2.5 M) - histopathologic, histoenzymatic, electron microscopic and biochemical studies.

作者信息

Mandache F, Pambuccian G, Stratulat S, Cantaragiu S, Moldoveanu E, Constantinescu S, Savi G, Mandache E

出版信息

Physiologie. 1980 Jul-Sep;17(3):191-6.

PMID:6779292
Abstract

The selective inhibitory effect of sodium salicylate (2.5 M) on the adrenal medulla was investigated histopathologically, histoenzymatically, electron microscopically and biochemically. It was proved that the different behaviour of nicotinamide-adenine dinucleotide (NAD) and nicotinamide-adenine dinucleotide phosphate (NADP) linked dehydrogenases under the action of sodium salicylate can account for the survival of cortical cells, while the medullar ones are necrosed.

摘要

通过组织病理学、组织酶学、电子显微镜检查及生物化学方法,研究了水杨酸钠(2.5M)对肾上腺髓质的选择性抑制作用。结果证明,在水杨酸钠作用下,烟酰胺腺嘌呤二核苷酸(NAD)和烟酰胺腺嘌呤二核苷酸磷酸(NADP)连接的脱氢酶表现不同,这可以解释皮质细胞得以存活,而髓质细胞发生坏死的原因。

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Physiologie. 1980 Jul-Sep;17(3):191-6.
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