Isseroff A
Psychopharmacology (Berl). 1980;69(2):179-81. doi: 10.1007/BF00427646.
When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in the delay task, nor were there any significant differences between groups in spontaneous alternation with no intertrial delay. The facilitative effect may be attributable to anomalies in areas, such as the limbic system, that continue to develop postnatally and mature in late infancy.
在成年期进行测试时，在10 - 29日龄或23 - 29日龄时每天接受50毫克/千克盐酸羟嗪皮下注射的雄性大鼠，相对于注射生理盐水的大鼠，在延迟自发交替行为表现上有显著促进作用。在10 - 16日龄时进行处理，在延迟任务中未产生显著促进作用，并且在没有试验间隔延迟的自发交替行为中，各组之间也没有显著差异。这种促进作用可能归因于诸如边缘系统等在出生后继续发育并在婴儿晚期成熟的区域的异常。
