Pekary A E, Hershman J M, Sawin C T
Acta Endocrinol (Copenh). 1980 Dec;95(4):472-8. doi: 10.1530/acta.0.0950472.
Basal serum TSH and the peak TSH response to a 500 micrograms TRH bolus were measured in 57 euthyroid and in 29 hypothyroid subjects either receiving graded thyroid hormone replacement or acutely removed from full replacement therapy. Serum TSH, total T4 and T3 were determined by sensitive radioimmunoassay methods. The peak versus basal TSH data for hypothyroid patients were linear within individuals. The regression slope of the peak versus basal TSH data for all hypothyroid subjects did not differ significantly from the corresponding slope for all euthyroid subjects. Basal and peak TSH versus T3 and T4 data for hypothyroid patients were also linear within each individual. Moreover, the regression of the basal TSH values averaged over the non-replacement to full replacement state against the TSH versus T3 slope had a significant negative correlation. This trend leads to an array of regression lines which average to the familiar hyperbolic relationship between thyrotrophin and thyroid hormone levels in man.
在57名甲状腺功能正常和29名甲状腺功能减退的受试者中，测量了基础血清促甲状腺激素（TSH）以及对500微克促甲状腺激素释放激素（TRH）推注的TSH峰值反应，这些受试者要么接受分级甲状腺激素替代治疗，要么突然停止完全替代治疗。血清TSH、总T4和T3通过灵敏的放射免疫测定法测定。甲状腺功能减退患者的TSH峰值与基础值数据在个体内呈线性关系。所有甲状腺功能减退受试者的TSH峰值与基础值数据的回归斜率与所有甲状腺功能正常受试者的相应斜率无显著差异。甲状腺功能减退患者的基础和峰值TSH与T3和T4数据在每个个体内也呈线性关系。此外，从无替代到完全替代状态平均的基础TSH值与TSH对T3斜率的回归具有显著的负相关性。这种趋势导致一系列回归线，这些回归线平均形成了人类促甲状腺激素与甲状腺激素水平之间熟悉的双曲线关系。
