Klein B, Bessler H, Lewinski U H, Cohen A M, Djaldetti M
Acta Haematol. 1980;64(5):246-50. doi: 10.1159/000207275.
6 patients with acute leukemia are described. All of them suffered from high temperature and malaise, and showed negative urine and blood cultures. High doses of gentamicin, cephalothin and cerebenicillin failed to lower the fever. The temperature became normal after administration of chloramphenicol (CAP) 2.0 g/day. In 3 out of 6 patients the peripheral blood blast cell count decreased following CAP administration. Incubation of acute lymphoblastic leukemia cells with CAP in vitro showed a marked decrease in the DNA synthesizing activity of the leukemic cells. The role of CAP as an additional tool in the treatment of acute leukemia is discussed.
本文描述了6例急性白血病患者。他们均有高热和全身不适症状，尿液和血液培养均为阴性。大剂量庆大霉素、头孢菌素和头孢苄青霉素均未能退热。给予氯霉素（CAP）2.0g/天后体温恢复正常。6例患者中有3例在使用CAP后外周血原始细胞计数下降。体外将急性淋巴细胞白血病细胞与CAP共同孵育显示白血病细胞的DNA合成活性显著降低。本文讨论了CAP作为治疗急性白血病辅助手段的作用。
