Vaziri N D, Byrne C, Ryan G, Wilson A
Am J Gastroenterol. 1980 Oct;74(4):328-31.
Ingestion of food leads to a rise in urinary pH. This phenomenon is commonly known as "postprandial alkaline tide" and is generally attributed to acid secretion in the stomach. To examine this hypothesis, we studied the changes of urinary pH, H+ concentration, PCO2, and bicarbonate in nine healthy volunteers with and without histamine H2 receptor blockade, using cimetidine and placebo medication. Postprandial alkaline tide persisted and was even exaggerated during treatment with cimetidine. Preservation of postprandial urinary alkaline tide, despite the expected inhibition of gastric acid secretion by cimetidine, tends to exclude a causal relation between alkaline tide and gastric acid secretion.
摄入食物会导致尿液pH值升高。这种现象通常被称为“餐后碱潮”，一般归因于胃内的酸分泌。为了检验这一假设，我们使用西咪替丁和安慰剂药物，研究了9名健康志愿者在有或没有组胺H2受体阻断情况下尿液pH值、H⁺浓度、PCO₂和碳酸氢盐的变化。餐后碱潮持续存在，甚至在西咪替丁治疗期间有所加剧。尽管西咪替丁预期会抑制胃酸分泌，但餐后尿碱潮依然存在，这倾向于排除碱潮与胃酸分泌之间的因果关系。
