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[高活性物质浓度的丹曲林溶液。初步交流(作者译)]

[Dantrolen solution of high active substance concentration. Preliminary communication (author's transl)].

作者信息

Rommelsheim K, Lauven P, Westhofen P, Stenger I, Stoeckel H

出版信息

Anasth Intensivther Notfallmed. 1980 Oct;15(5):423-7.

PMID:6779658
Abstract

The effectivity of treatment of a dramatically progressing malignant hyperthermia with Dantrolen depends, inter alia, on the easy production and applicability of the preparation. The modification described in this article, of an intravenously injectable Dantrolen solution which contains 10.0 mg active substance in 1.0 ml of a mixture of ethanol, glycerin and water, seems to meet these conditions, as established by experimental investigation.

摘要

用丹曲林治疗急剧进展的恶性高热的有效性,尤其取决于该制剂的易于生产和适用性。本文所述的丹曲林静脉注射溶液的改良制剂,在1.0毫升乙醇、甘油和水的混合液中含有10.0毫克活性物质,经实验研究证实,似乎符合这些条件。

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1
[Dantrolen solution of high active substance concentration. Preliminary communication (author's transl)].[高活性物质浓度的丹曲林溶液。初步交流(作者译)]
Anasth Intensivther Notfallmed. 1980 Oct;15(5):423-7.
2
[On the treatment of malignant hyperthermia. A simple method of preparing a dantrolene sodium solution (author's transl)].[关于恶性高热的治疗。制备丹曲林钠溶液的一种简单方法(作者译)]
Anaesthesist. 1981 May;30(5):257-8.
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[Malignant hyperthermia in swine during isoflurane anesthesia].[猪在异氟烷麻醉期间的恶性高热]
Dtsch Tierarztl Wochenschr. 1994 May;101(5):207-8.
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[An original technic for the preparation of an injectable solution of sodium dantrolene from oral capsules (Dantralen) or from the pure substance].[一种从口服胶囊(丹曲林)或纯物质制备丹曲林钠注射溶液的原创技术]
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[Malignant hyperthermia. Current aspects of dantrolene treatment of 2 cases of hyperthermia maligna incipiens].[恶性高热。丹曲林治疗2例初发性恶性高热的现状]
Anasth Intensivther Notfallmed. 1982 Jun;17(3):169-70.
6
[Experimental study of dantrolene sodium in anesthetic malignant hyperthermia in the pietrain-strain pig].
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7
[Neuroleptic malignant syndrome. Beneficial effects of dantrolene on hyperthermia and hypertonia (author's transl)].[抗精神病药恶性综合征。丹曲林对高热和张力亢进的有益作用(作者译)]
Nouv Presse Med. 1982 Mar 27;11(14):1067-9.
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[Successful treatment of malignant hyperthermia with dantrolene-sodium and uneventful re-anaesthesia after oral dantrolene-prophylaxis (author's transl)].
Anaesthesist. 1982 May;31(5):241-4.
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Halothane induced porcine malignant hyperthermia reversed by dantrolene.氟烷诱发的猪恶性高热被丹曲林逆转。
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[Malignant hyperthermia. II. Investigation of the patient's family (author's transl)].[恶性高热。II. 患者家族调查(作者译)]
Anaesthesist. 1980 Feb;29(2):94-8.