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嗜铬细胞瘤中的硝酸甘油与麻醉(作者译)

[Nitroglycerin and anaesthesia in phaeochromocytoma (author's transl)].

作者信息

Chelly J, Kieffer J P, Tournay D, Passelecq J

出版信息

Anesth Analg (Paris). 1980;37(5-6):325-30.

PMID:6779673
Abstract

Six patients who have undergone surgery for phaeochromacytoma have been separated in 2 groups. In group I (n = 3) a nitroglycerin infusion of 7.8 microgram . kg-1 . mn-1 has been used before the removal of the tumor and no vasodilator drug was infused in group II. During the dissection, mean arterial pressure was significantly lower in group I (129 +/- 12 mm Hg) than in group II (172 +/- 17 mm Hg) (p < 0.05). After removal of the tumor the decrease in mean arterial pressure was lower in group I than in group II. In group I the maximal rise in mean arterial pressure (73 +/- 18 mm Hg) was significantly reduced compared to group II (134 +/- 20 mm Hg). These results show that nitroglycerin is an interesting substance to decrease the variations of arterial blood pressure and this effect is important to prevent cardiac complications during and after surgery.

摘要

6例接受嗜铬细胞瘤手术的患者被分为2组。在第一组(n = 3)中,在切除肿瘤前使用了7.8微克·千克⁻¹·分钟⁻¹的硝酸甘油输注,而第二组未输注血管扩张剂。在解剖过程中,第一组的平均动脉压(129±12毫米汞柱)显著低于第二组(172±17毫米汞柱)(p < 0.05)。切除肿瘤后,第一组平均动脉压的下降幅度低于第二组。与第二组(134±20毫米汞柱)相比,第一组平均动脉压的最大升高幅度(73±18毫米汞柱)显著降低。这些结果表明,硝酸甘油是一种可降低动脉血压波动的有益物质,这种作用对于预防手术期间及术后的心脏并发症很重要。

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