Preliminary data on dipropylacetamide absorption in rats.

Absorption of dipropylacetamide, after oral and i.m. administration, was studied in different groups of male albino Wistar rats. After i.m. administration, only unmodified amide was found in plasma, whereas oral administration of the drug was followed by the presence of dipropylacetic acid and dipropylacetamide in plasma. This last compound resulted in a higher amount in a further group of rats previously treated with neomycin in order to avoid the action of intestinal flora. Present results seem to exclude an hepatic role in the transformation of dipropylacetamide in dipropylacetic acid.