D'Oliveira M, Sykes M K, Chakrabarti M K, Orchard C, Keslin J
Br J Anaesth. 1981 Jan;53(1):11-8. doi: 10.1093/bja/53.1.11.
The pulmonary vasoconstrictor response to the unilateral administration of 7% oxygen was studied in 10 anaesthetized dogs in which the lungs were mechanically ventilated. The distribution of blood flow between the two lungs was measured continuously by recording the radioactivity in the mixed expired gas from each lung during the infusion i.v. of xenon-133. Infusions of nitroglycerine and sodium nitroprusside which produced the same decrease in mean aortic pressure produced similar decreases in hypoxic pulmonary vasoconstriction. The reduction in arterial PO2 during unilateral hypoxia was greater when the hypoxic vasoconstrictor response was depressed by drugs than it was during the control periods, although mixed venous PO2 was unchanged. It is concluded that both drugs may cause hypoxaemia by increasing the blood flow to alveoli with a low ventilation/perfusion ratio.
在10只接受机械通气的麻醉犬中，研究了单侧给予7%氧气时的肺血管收缩反应。通过在静脉输注氙-133期间记录来自每侧肺的混合呼出气体中的放射性，连续测量两侧肺之间的血流分布。输注硝酸甘油和硝普钠使平均主动脉压产生相同程度的下降，同时也使低氧性肺血管收缩产生类似程度的降低。当低氧性血管收缩反应被药物抑制时，单侧低氧期间动脉血氧分压的降低幅度大于对照期，尽管混合静脉血氧分压未变。得出的结论是，两种药物都可能通过增加血流至通气/灌注比值低的肺泡而导致低氧血症。
