O'Brien M D, Upton A R, Toseland P A
Br Med J (Clin Res Ed). 1981 Jan 17;282(6259):178-80. doi: 10.1136/bmj.282.6259.178.
Primidone given to a patient for epilepsy produced an unexpected reduction in benign familial tremor. Over the next eight years the drug was therefore tried in a prospective study of 20 other patients with benign familial tremor alone. Of these, six could not tolerate the drug because of vertigo and nausea but 12 obtained a good response, which in some cases was dramatic. Investigations in two patients suggested that the effect was mediated predominantly by derived phenylethylmalonamide, though primidone had some effect, since tremor recurred slightly on withdrawing the drug despite a constant or rising blood phenylethylmalonamide concentration. Primidone is highly effective in benign familial tremor. More patients with the condition are intolerant of the drug than are usually found with epilepsy.
给予一名癫痫患者的扑米酮意外减轻了其良性家族性震颤。因此，在接下来的八年里，对另外20名单纯患有良性家族性震颤的患者进行了一项前瞻性研究，试用了这种药物。其中，6名患者因眩晕和恶心无法耐受该药物，但12名患者获得了良好的反应，在某些情况下效果显著。对两名患者的研究表明，这种效果主要是由衍生的苯乙丙二酰胺介导的，尽管扑米酮也有一定作用，因为尽管血液中苯乙丙二酰胺浓度持续或上升，但停药后震颤仍略有复发。扑米酮对良性家族性震颤非常有效。与癫痫患者相比，患有这种疾病而不耐受该药物的患者更多。
