Bartke A, Siler-Khodr T M, Hogan M P, Roychoudhury P
Endocrinology. 1981 Jan;108(1):133-9. doi: 10.1210/endo-108-1-133.
It was previously reported that PRL can stimulate FSH release in immature female rats and PRL-deficient male dwarf mice. We have examined the effects of PRL-producing ectopic pituitary grafts on plasma FSH and LH levels in adult male golden hamsters during exposure to both long (14 h of light, 10 h of darkness) and short (5 h of flight, 19 h of darkness) photoperiods. In both groups, the presence of one pituitary graft resulted in a significant elevation of pituitary and plasma FSH levels. Although there were no statistically significant changes in the concentration of LH in the pituitary or plasma of either group. LH values were more variable than FSH values, and these findings do not rule out an effect on LH. To determine whether the ability of ectopic pituitary grafts to stimulate FSH release depends on changes in testicular or adrenal function, additional experiments were done in castrated male hamsters, in castrated males given testosterone propionate, and in castrated adrenalectomized hamsters maintained with injections of cortisol. The results indicate that the increase in FSH release in engrafted animals does not depend on the testes or the adrenals, but can be prevented by exogenous cortisol. In adult female hamsters, pituitary grafts increased plasma LH levels above the concentrations observed in diestrous, proestrous, or pregnant controls, but did not alter plasma FSH levels. In contrast, in ovariectomized and ovariectomized-estradiol benzoate-treated animals, pituitary grafts increased plasma FSH levels without significantly affecting plasma LH. It is concluded that PRL-producing ectopic pituitary homografts significantly stimulate FSH synthesis and release in male golden hamsters, and that this effect is probably not mediated through the changes in gonadal or adrenal function.
先前有报道称，催乳素（PRL）可刺激未成熟雌性大鼠和催乳素缺乏的雄性侏儒小鼠释放促卵泡激素（FSH）。我们研究了在长光照周期（14小时光照，10小时黑暗）和短光照周期（5小时光照，19小时黑暗）条件下，产生PRL的异位垂体移植对成年雄性金黄仓鼠血浆FSH和促黄体生成素（LH）水平的影响。在两组中，存在一个垂体移植均导致垂体和血浆FSH水平显著升高。尽管两组垂体或血浆中LH浓度均无统计学上的显著变化。LH值比FSH值更具变异性，这些发现并不排除对LH有影响。为了确定异位垂体移植刺激FSH释放的能力是否取决于睾丸或肾上腺功能的变化，我们对去势雄性仓鼠、给予丙酸睾酮的去势雄性仓鼠以及通过注射皮质醇维持的去势肾上腺切除仓鼠进行了额外实验。结果表明，移植动物中FSH释放的增加不依赖于睾丸或肾上腺，但可被外源性皮质醇阻止。在成年雌性仓鼠中，垂体移植使血浆LH水平高于动情间期、动情前期或怀孕对照组中观察到的浓度，但未改变血浆FSH水平。相反，在去卵巢和去卵巢并用苯甲酸雌二醇处理的动物中，垂体移植增加了血浆FSH水平，而对血浆LH无显著影响。得出的结论是，产生PRL的异位垂体同种移植显著刺激雄性金黄仓鼠FSH的合成和释放，并且这种作用可能不是通过性腺或肾上腺功能的变化介导的。
